Carried by: GGC (Genetic and Cancer Group)
References:
Clinician(s): Chrystelle COLAS, Catherine NOGUÈS
Biologist(s): Lisa GOLMARD, Ahmed BOURAS
Presentation
- Isolated solid tumour
- At an unusually young age for the location and without risk factors
- Examples of age limits used for common cancers: breast cancer <25 years; epithelial ovarian cancer <40 years; prostate cancer <45 years; pancreatic cancer <40 years old; colorectal cancer <20 years old; kidney cancer <30 years old
- Or the presence of syndromic features
- Or multiple primary tumours in the same individual
- 4 or more in different organs (excluding basal cell cancers and environmental cancers after discussion in the multidisciplinary team meeting)
- The first occurring before the age of 60
Conditions for analysis:
- Either both parents are available for sampling: constitutional analysis in trio
- Or frozen samples from at least one of the tumours are available: constitutional and comparative tumour analysis
Criteria before considering a discussion in MDM-FMG
- The patient must be available for a new blood sample and informed that their case will be presented at a multidisciplinary team meeting
- Relatives must be available :
- For isolated cases, both parents should be available (trio analysis).
- For familial cases, affected relatives should be available.
- Tumours must be anatomopathologically confirmed, with samples available from the index case and affected relatives.
- Appropriate routine constitutional and/or tumour genetic analyses must have been performed.
- Frozen tumour material should be available (optional).
- The case should preferably have been discussed at a local multidisciplinary team meeting prior to submission.
Genome Sequencing in diagnostic strategy
MDM cartography
MDM
Type of the MDM
City of the coordinator
Name, first name, and email of the contact
MDM GGC FMG
National
Paris
Chrystelle COLAS
chrystelle.colas@curie.fr
Hélène DELHOMELLE
helene.delhomelle@curie.fr